https://www.drugtargetreview.com
In experiments with mice, researchers have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs; the idea behind the experiments, developed by Johns Hopkins Medicine, was to exploit the natural tendencies of costimulatory signals to train the immune system to accept transplanted cells as self-permanently. To do that, they used two antibodies, CTLA4-Ig and anti-CD154, which keep T cells from beginning an attack when encountering foreign particles by binding to the T-cell surface. The study was published in the journal Brain